D. Gackowski et al., Background level of 8-oxo-2 '-deoxyguanosine in lymphocyte DNA does not correlate with the concentration of antioxidant vitamins in blood plasma, ACT BIOCH P, 48(2), 2001, pp. 535-539
Antioxidant vitamins, being effective free radical scavengers, can protect
cellular DNA from oxidative damage. Therefore, in the present study we repo
rt on the relationship between basal level of 8-oxo-2'-deoxyguanosine in hu
man lymphocyte DNA and the concentration of antioxidant vitamins (A, C and
E). The average level of 8-oxo-2'-adeoyguanosine in lymphocytes of the stud
ied group (15 males and 20 females) was 9.57 per 10(6) dG molecules. The en
dogenous level of ascorbic acid (vitamin C) in the plasma was, on average,
56.78 muM, while the mean concentrations of retinol (vitamin A) and alpha -
tocopherol (vitamin E) were 1.24 muM and 25.74 muM, respectively. No correl
ations were found between individual 8-oxo-2'-deoxyguanosine levels in lymp
hocyte DNA and endogenous concentration of the vitamins.