M. Mergler et U. Klinner, Cell density-correlated induction of pyruvate decarboxylase under aerobic conditions in the yeast Pichia stipitis, ACT BIOL HU, 52(2-3), 2001, pp. 265-269
During the aerobic batch cultivation of P. stipitis CBS 5776 with glucose,
pyruvate decarboxylase was activated in a cell number-correlated manner. Ac
tivation started when a cell number between 7x10(7) and 1x10(8) cells ml(-1
) was reached and the enzyme activity increased during further cultivation.
This induction might have been triggered either by an unknown quorum sensi
ng system or by a shortage of cytoplasmic acetyl-CoA.