Oral tolerance is an active non-response to antigens delivered via the oral
route. Mechanisms governing tolerance induction have been well characteriz
ed in mouse. Similar studies in man are lacking, although there is evidence
that tolerance can be induced. In disease states, tolerance is altered and
this may account for the presence of mucosal inflammation. In food hyperse
nsitivity there is evidence that allergens may be handled differently and t
his may play a role in disease expression.