P. Goya et al., HETEROCYCLIC STRUCTURES USEFUL IN MEDICINAL CHEMISTRY - THE CASE OF PYRAZINO[2,3-C][1,2,6]THIADIAZINE 2,2-DIOXIDE, Il Farmaco, 52(5), 1997, pp. 283-287
Different aspects of a particular kind of heterocycle, namely pyrazino
[2,3-c][1,2,6]thiadiazine 2,2-dioxide are discussed. These include syn
thesis, reactivity, tautomerism and acid-base properties, results of x
-ray analysis and molecular orbital calcultations. Besides, some of th
e derivatives have shown interesting biological effects, among which a
re the diuretic properties which are also presented.