Occupation and leukemia: A population-based case-control study in Iowa andMinnesota

Background Studies have suggested that risk of leukemia may be associated w ith occupational or industrial exposures and risk may vary by the histologi cal type of the disease. Methods A population-based case-control study was conducted in Iowa and Min nesota to evaluate the association between various occupations, industries, and occupational exposures and leukemia risk. A total of 513 cases and 1,0 87 controls was included in the study. A lifetime occupational history and other risk factor information were collected through in-person interviews, and a job-exposure matrix was used to assess possible risks associated with specific exposures. Results A significantly increased risk of leukemia was observed among agric ultural service industries and among nursing and healthcare workers. Janito rs, cleaners, and light truck drivers also experienced increased risk. Thos e employed in plumbing, heating and air conditioning industries, and sales of nondurable goods (such as paints and varnishes) had an increased risk. P rinters, painters, and workers in the food and metal industries had a nonsi gnificantly increased risk of leukemia. Analyses by specific exposures and histology of leukemia showed that risk of leukemia associated with occupati onal or industrial exposures may vary by histological type of the disease. Conclusions An increased risk of leukemia among workers employed in agricul tural industries, nursing and healthcare workers, and in a few occupations with possible exposure to solvents is consistent with earlier studies. Asso ciations of risk with occupations not observed previously deserve further a ssessment. Published 2001 Wiley-Liss, Inc.(dagger).