Recent evidence that 5HT-2A may be subjected to genomic imprinting prompted
us to examine a collection of Irish family trios (an affected individual a
nd both parents) for evidence of an association between 5HT-2A and bipolar
disorder. Family trios offer an advantage over case control studies in rega
rd to genomic imprinting since with family trios it is possible to trace th
e path of alleles from the parents to the offspring. Using haplotype-based
haplotype relative risk (HHRR) and transmission/disequilibrium (TDT) analys
es, no evidence was found for an association of 5HT-2A with bipolar affecti
ve disorder under the assumption of no imprinting and of imprinting. (C) 20
01 Wiley-Liss, Inc.