No association between 5HT-2A and bipolar disorder irrespective of genomicimprinting

Recent evidence that 5HT-2A may be subjected to genomic imprinting prompted us to examine a collection of Irish family trios (an affected individual a nd both parents) for evidence of an association between 5HT-2A and bipolar disorder. Family trios offer an advantage over case control studies in rega rd to genomic imprinting since with family trios it is possible to trace th e path of alleles from the parents to the offspring. Using haplotype-based haplotype relative risk (HHRR) and transmission/disequilibrium (TDT) analys es, no evidence was found for an association of 5HT-2A with bipolar affecti ve disorder under the assumption of no imprinting and of imprinting. (C) 20 01 Wiley-Liss, Inc.