FUROXAN DERIVATIVES AS NO-DONORS

In this work the synthesis and the study of both the NO-donating prope rties and in vitro vasodilating activities of a series of water solubl e furoxans are reported. Results obtained show that appropriate substi tution on the furoxan ring allows modulation of NO-donating properties over a wide range as well as spontaneous NO-release in physiological conditions. Correlation between the initial rates of the NO-release an d the in vitro vasodilating potencies of the water soluble furoxans an alyzed is also discussed.