Comparison between capillary electrophoresis, liquid chromatography, potentiometric and spectrophotometric techniques for evaluation of pK(a) values of zwitterionic drugs in acetonitrile-water mixtures

Authors
Barbosa, J Barron, D Jimenez-Lozano, E Sanz-Nebot, V
Citation
J. Barbosa et al., Comparison between capillary electrophoresis, liquid chromatography, potentiometric and spectrophotometric techniques for evaluation of pK(a) values of zwitterionic drugs in acetonitrile-water mixtures, ANALYT CHIM, 437(2), 2001, pp. 309-321
Citations number
49
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
ANALYTICA CHIMICA ACTA
ISSN journal
00032670 → ACNP
Volume
437
Issue
2
Year of publication
2001
Pages
309 - 321
Database
ISI
SICI code
0003-2670(20010627)437:2<309:CBCELC>2.0.ZU;2-6
Abstract
Capillary electrophoresis, liquid chromatography, potentiometry and UV-visi ble spectrophotometry are frequently used for determination of pK(a) values of substances. In this work, we have compared the application of the diffe rent techniques to the determination of pK(a) values of a series of zwitter ionic quinolones in acetonitrile-water mixtures, emphasizing the advantages of capillary electrophoresis for the determination of equilibrium constant s of widely used drugs in aqueous and organic media. (C) 2001 Elsevier Scie nce B.V. All rights reserved.