Wr. Wilson et al., High-dose intra-arterial cisplatin therapy followed by radiation therapy for advanced squamous cell carcinoma of the head and neck, ARCH OTOLAR, 127(7), 2001, pp. 809-812
Objective: To assess the effectiveness of a protocol consisting of 4 cycles
of high-dose intra-arterial cisplatin infusions followed by radiation ther
apy for improving chemotherapy response rates, organ preservation, and surv
ival in patients with advanced-stage untreated and previously treated squam
ous cell carcinoma of the head and neck.
Design and Setting: A prospective study of sequentially enrolled patients t
reated in an academic medical center. The Kaplan-Meier method was used for
survival analysis.
Patients: Fifty-eight nonpregnant adults, 18 years of age or older, with me
asurable untreated or recurrent advanced biopsy-proven squamous cell carcin
oma of the head and neck.
Main Outcome Measures: Response rate to targeted intra-arterial cisplatin i
nfusions, organ preservation, and survival.
Results: Fifty-eight patients (44 men and 14 women) were followed up for at
least 2 years (median duration of follow-up, 27 months). Twenty-nine (67%)
of the 43 previously untreated patients had a complete response to intra-a
rterial cisplatin therapy. Of the untreated patients, 28 are alive and dise
ase free after a median follow-up time of 30 months. Five of the patients w
ith recurrent disease had a complete response to intraarterial cisplatin th
erapy. There were 4 survivors after a median follow-up time of 17.5 months.
Of note, there were no deaths or serious complications related to the trea
tment in either group.
Conclusions: High-dose intra-arterial cisplatin therapy provides a high com
plete and partial response rate (91%). The combination of high-dose intra-a
rterial cisplatin and radiation therapy is effective in improving survival
and organ preservation rates in patients with previously untreated, advance
d squamous cell carcinoma of the head and neck. This treatment protocol is
much less effective for recurrent disease.