Population dynamics of a scrapie outbreak

A detailed analysis of a scrapie outbreak in a flock of Cheviot sheep is de scribed. A total of 33 cases of 1473 sheep born to the flock were reported between 1985 and 1994. The epidemiology of scrapie can only be understood w ith reference to sheep demography, the population genetics of susceptibilit y to scrapie, pathogenesis during a long incubation period, and the rate of transmission (by both horizontal and vertical routes), all of which intera ct in complex ways. In recent work a mathematical model incorporating these elements was developed and successfully reproduced key features of an earl ier outbreak of scrapie in this flock, Here an application of the model to the second outbreak is described. The model accurately reproduces observed allele frequencies and total numbers of susceptible animals remaining at th e end of the outbreak. A major difference between the two outbreaks is the very much lower force of infection in the second outbreak. This provided ad ditional information which suggested two ways in which our existing assumpt ions be refined; firstly, older animals have reduced susceptibility to scra pie and secondly, homozygous and heterozygous susceptibles have different i ncubation periods.