Y. Almirantis et A. Provata, An evolutionary model for the origin of non-randomness, long-range order and fractality in the genome, BIOESSAYS, 23(7), 2001, pp. 647-656
We present a model for genome evolution, comprising biologically plausible
events such as transpositions inside the genome and insertions of exogenous
sequences. This model attempts to formulate a minimal proposition accounti
ng for key statistical properties of genomes, avoiding, as far as possible,
unsupportable hypotheses for the remote evolutionary past. The statistical
properties that are observed in genomic sequences and are reproduced by th
e proposed model are: (i) deviations from randomness at different length sc
ales, measured by suitable algorithms, (ii) a special form of size distribu
tion (power law distribution) characterising different levels of genome org
anisation in the non-coding, and (iii) extensive resemblance in the alterna
tion of coding and non-coding regions at several length scales (self-simila
rity) in long genomic sequences of higher eukaryotes, BioEssays 23:647-656,
2001. (C) 2001 John Wiley & Sons, Inc.