Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase

Authors
Cuq, P Rouquet, C Evrard, A Ciccolini, J Vian, L Cano, JP
Citation
P. Cuq et al., Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase, BR J CANC, 84(12), 2001, pp. 1677-1680
Citations number
20
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
84
Issue
12
Year of publication
2001
Pages
1677 - 1680
Database
ISI
SICI code
0007-0920(20010615)84:12<1677:FSOHMB>2.0.ZU;2-K
Abstract
The relationship between uridine phosphorylase (UP) expression level in can cer cells and the tumour sensitivity to fluoropyrimidines is unclear. In th is study, we found that UP overexpression by gene transfer, and the subsequ ent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucl eotide pathway, does not increase the fluoropyrimidine sensitivity of MCF-7 human cancer cells. (C) 2001 Cancer Research Campaign.