Anti-TNF therapy and malignancy - A critical review

Authors
Cohen, RB Dittrich, KA
Citation
Rb. Cohen et Ka. Dittrich, Anti-TNF therapy and malignancy - A critical review, CAN J GASTR, 15(6), 2001, pp. 376-384
Citations number
77
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
CANADIAN JOURNAL OF GASTROENTEROLOGY
ISSN journal
08357900 → ACNP
Volume
15
Issue
6
Year of publication
2001
Pages
376 - 384
Database
ISI
SICI code
0835-7900(200106)15:6<376:ATAM-A>2.0.ZU;2-K
Abstract
The roles of tumour necrosis factor (TNF) and anti-TNF ther apy in malignan cy are reviewed, including an overview of baseline risk factors for maligna ncy in inflammatory diseases and the incidences of malignancies observed in clinical trials of an anti-TNF-alpha therapy, infliximab. The preclinical data and early clinical experience presented for infliximab do not provide evidence for a causal relationship between TNF a antagonism and the develop ment of lymphoid or nonlymphoid cancers.