Nm. Lakkis et al., Use of ICHOR-platelet works to assess platelet function in patients treated with GP IIb/IIIa inhibitors, CATHET C IN, 53(3), 2001, pp. 346-351
Platelet glycoprotein GP IIb/IIIa inhibitors have been recently approved fo
r use in treating patients with acute coronary syndromes and those undergoi
ng PCI. The purpose of this study was to assess the feasibility of using a
new device, the ICHOR platelet works, to detect platelet inhibition in pati
ents undergoing PCI and treated with abciximab or tirofiban, The study was
conducted at Baylor College of Medicine, Houston, Texas. Thirty patients un
dergoing PCI and treated with abciximab (n = 10) or tirofiban (n = 20) are
included. Blood samples were obtained before, at 30 min, at 4 hr, and at 12
hr after starting the GP IIb/IIIa inhibitors and 2 hr after discontinuatio
n. Baseline studies revealed > 95% platelet aggregability in all patients a
fter exposure to ADP (20 muM). After starting tirofiban, 82%, 83%, and 82%
of platelets were inhibited at 30 min, 4 hr, and 12 hr. Platelet inhibition
decreased to 43% 2 hr after discontinuation of tirofiban. Similarly, ICHOR
platelet works detected 91%, 92%, and 85% platelet inhibition at 30 min, 4
hr, and 12 hr after starting abciximab, respectively. Platelet inhibition
decreased to 73% 2 hr after discontinuation. The ICHOR platelet works is a
promising, simple, and rapid bedside method that may have clinical utility
in assessing platelet inhibition in patients treated with GP IIb/IIIa inhib
itors. (C) 2001 Wiley-Liss, Inc.