The inclusion compound of a new ionizable derivative of beta-cyclodextrin with ferrocenium drug

A new beta -cyclodextrin (beta -CD) derivative, mono(6-deoxy-6-(2-butenedin itrile-2,3-dimercapto sodium salt)]-beta- CD (6-mnt-beta -CD), and its incl usion compound with a ferrocenium drug, have been prepared and characterize d by. IR, UV, C-13-NMR spectroscopy, and mass spectrometry, elemental analy sis, thermogravimetry, and cyclic voltammetry (CV). The interplay between t he side-arm anion of beta -CD and the ferrocenium (guest) in the inclusion compound 6-mnt-beta -CD-/Fc(+) has been investigated by C-13-NMR, UV, IR, a nd thermogravimetric methods. Charge transfer from the anion to the cation in 6-mnt-beta -CD-/Fc(+) was then experimentally identified. The interactio n between the guest and the host with side-arm in 6-mnt-beta -CD-/Fc(+) res ulted in smaller positive potential shifts compared to that in the inclusio n compound [beta -CD/Fc(+)]BF4-.