Studies on new platelet aggregation inhibitors 1. Synthesis of 7-nitro-3,4-dihydroquinoline-2(1H)-one derivatives

Authors
Iyobe, A Uchida, M Kamata, K Hotei, Y Kusama, H Harada, H
Citation
A. Iyobe et al., Studies on new platelet aggregation inhibitors 1. Synthesis of 7-nitro-3,4-dihydroquinoline-2(1H)-one derivatives, CHEM PHARM, 49(7), 2001, pp. 822-829
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
49
Issue
7
Year of publication
2001
Pages
822 - 829
Database
ISI
SICI code
0009-2363(200107)49:7<822:SONPAI>2.0.ZU;2-9
Abstract
A series of 6-cyclic aliphatic amino-7-nitro-3,4-dihydroquinoline-2(1H) wer e prepared and tested for platelet aggregation inhibitory effect, cardioton ic activity and chronotropic activity, These compounds appeared to show sel ective inhibitory activity against platelet aggregation. Among them, 6-(4-e thoxycarbonylpiperidino)-7-nitro-3,4-dihydroquinoline-2(1H)-one (22f) showe d the most potent inhibitory activity and high selectivity. A divergent syn thetic route to 6-cyclic aliphatic amino-7-nitro-3,4-dihydroquinoline-2(1H) -one derivatives has also been investigated.