Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin

Authors
Sandercock, AM Charles, EH Scaife, W Kirkpatrick, PN O'Brien, SW Papageorgiou, EA Spencer, JB Williams, DH
Citation
Am. Sandercock et al., Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin, CHEM COMMUN, (14), 2001, pp. 1252-1253
Citations number
14
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
14
Year of publication
2001
Pages
1252 - 1253
Database
ISI
SICI code
1359-7345(2001):14<1252:BOTDCO>2.0.ZU;2-1
Abstract
The biosynthetic pathway to the L-di-meta-hydroxyphenylglycine (DHPG) const ituent of chloroeremomycin (A82846B), has been investigated by a combinatio n of feeding experiments with C-13-labelled substrates, and expression and assay of HpgT from the chloroeremomycin biosynthetic cluster.