Serum granulocyte colony-stimulating factor in patients with chronic renalfailure

Objective To gain a better understanding of the regulatory mechanism and ki netic behaviour of granulocyte colony-stimulating factor (G-CSF). Methods An enzyme-linked immunosorbent assay (ELISA) method was used to det ect serum G-CSF in 61 patients with chronic renal failure +/- long-term hem odialysis and 30 normal controls. Results Serum G-CSF levels in CRF patients were significantly higher than i n normal controls. Eighty percent of patients had detectable G-CSF and seru m G-CSF levels were 566.40 +/- 207.98 ng/L in nonhemodialyzed (non-HD) pati ents. The detectable percentage in hemodialyzed patients was 93.33%, serum G-CSF levels in pre-HD and post-HD patients were 1255.36 +/- 611.25 ng/L an d 1151.61 +/- 599.47 ng/L respectively. Serum G-CSF levels in HD patients w ere slightly higher than in non-HD patients, but no significant difference was found between the two groups. No difference was found between the G-CSF values obtained in pre-HD and post-HD patients. There was no relationship between G-CSF levels and WBC, BUN or Scr (P > 0.05). Conclusion The high value of G-CSF in patients with CRF may be caused by a decrease in G-CSF clearance and/or an increase in G-CSF release.