We present 3 eyes that underwent photorefractive keratectomy (PRK) for
residual myopia after penetrating keratoplasty, and 1 eye that was tr
eated for recurrent granular dystrophy and myopia following penetratin
g keratoplasty. The 3 refractive eyes experienced improvements in visu
al acuity and refractive error through 3 months postoperative, but exh
ibited regression of effect after 6 months postoperative. One eye also
exhibited substantial corneal haze at three months postoperative that
was not responsive to steroid retreatment. The eye with granular dyst
rophy obtained symptomatic relief as well as improvement in vision. We
tentatively conclude that the corneal transplant reacts to photorefra
ctive keratectomy in much the same way as a normal cornea. Eyes with s
ubstantial degrees of post-graft myopia exhibit regression of refracti
ve effect, much like high myopes following primary photorefractive ker
atectomy. Photorefractive was unable to prevent the recurrence of gran
ular dystrophy in the transplanted tissue. The eyes reported here achi
eved only modest long-term visual and refractive improvements.