Microlissencephaly with cardiac, spinal and urogenital defects

We describe two children with a brain defect similar to that described as ' microlissencephaly', as defined in Barkovich er al. [(1998) Neuroped 29: 11 3-119], Concomitant malformations (cardiac, spinal, urogenital) mag represe nt components of a wider syndrome complex; alternatively, or additionally, there may have been a valproate teratogenic effect. The inheritance is like ly to be autosomal recessive, although X-linkage cannot be excluded. Clin D ysmorphol 10: 203-208 (C) 2001 Lippincott Williams & Wilkins.