Remission of the renal involvement in a patient with primary Sjogren's syndrome (SS) after pulse high-dose corticosteroid infusion therapy

We report the case of a young female patient with primary Sjogren's syndrom e (SS). In addition to sicca symptoms she also suffered from progressive re nal insufficiency and renal tubular acidosis (RTA). She was treated with th ree sets of pulse high-dose corticosteroid infusion and subsequent low-dose corticosteroid oral administration. When the efficacy was evaluated about 6 months after the start of the therapy, dramatic improvements were seen wi th no adverse effects, not only in laboratory tests but also histopathologi cally, as indicated by the repeat kidney biopsy. This suggests that renal i nvolvements of SS might be reversible in some cases, and that there might b e a clinical benefit of pulse high-dose corticosteroid infusion therapy in SS with progressive renal involvement.