Antigen presentation to CD8(+) T cells: cross-priming in infectious diseases

Authors
den Haan, JMM Bevan, MJ
Citation
Jmm. Den Haan et Mj. Bevan, Antigen presentation to CD8(+) T cells: cross-priming in infectious diseases, CURR OP IM, 13(4), 2001, pp. 437-441
Citations number
57
Categorie Soggetti
Immunology
Journal title
CURRENT OPINION IN IMMUNOLOGY
ISSN journal
09527915 → ACNP
Volume
13
Issue
4
Year of publication
2001
Pages
437 - 441
Database
ISI
SICI code
0952-7915(200108)13:4<437:APTCTC>2.0.ZU;2-B
Abstract
Recent studies indicate that. in most types of infections, antigen presenta tion by 'professional' bone-marrow-derived cells is essential for priming p athogen-specific CD8(+) T cells. This is true even in the absence of direct infection of these cells, which indicates that cross-priming is an essenti al component of the immune response against pathogens.