CD1-specific T cells in microbial immunity

Authors
Gumperz, JE Brenner, MB
Citation
Je. Gumperz et Mb. Brenner, CD1-specific T cells in microbial immunity, CURR OP IM, 13(4), 2001, pp. 471-478
Citations number
64
Categorie Soggetti
Immunology
Journal title
CURRENT OPINION IN IMMUNOLOGY
ISSN journal
09527915 → ACNP
Volume
13
Issue
4
Year of publication
2001
Pages
471 - 478
Database
ISI
SICI code
0952-7915(200108)13:4<471:CTCIMI>2.0.ZU;2-G
Abstract
Recent results strengthen evidence that CD1-restricted T cells play importa nt roles in host defense against microbial infections. Human subjects recen tly infected with Mycobacterium tuberculosis showed elevated responses to C D1c-mediated presentation of a microbial lipid antigen, compared with contr ol donors. Activation of CD1d-restricted NKT cells with a synthetic glycoli pid antigen results in improved immune responses to several infectious path ogens.