A new convenient synthesis of 3-carhoxycephems starting from 7-aminocephalosporanic acid (7-ACA)

Authors
Keltjens, R Vadivel, SK de Vroom, E Klunder, AJH Zwanenburg, B
Citation
R. Keltjens et al., A new convenient synthesis of 3-carhoxycephems starting from 7-aminocephalosporanic acid (7-ACA), EUR J ORG C, (13), 2001, pp. 2529-2534
Citations number
25
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
13
Year of publication
2001
Pages
2529 - 2534
Database
ISI
SICI code
1434-193X(200107):13<2529:ANCSO3>2.0.ZU;2-7
Abstract
New convenient syntheses of 3-carboxycephems starting from 7-ACA are report ed. All three possible cephem derivatives with respect to the position of t he double bond in the six-membered ring and oxidation state of the sulfur a tom have been synthesized in high overall yield.