SYNTHESIS, ANTIFUNGAL ACTIVITY AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-(ALKYL OR ARYL)-2-(ALKYL OR 1-YLMETHYL)-4-(POLYAZOL-1-YLMETHYL)-1,3-DIOXOLANES

Authors
BAJI H KIMNY T GASQUEZ F FLAMMANG M COMPAGNON PL DELCOURT A MATHIEU G VIOSSAT B MORGANT G NGUYENHUY D
Citation
H. Baji et al., SYNTHESIS, ANTIFUNGAL ACTIVITY AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-(ALKYL OR ARYL)-2-(ALKYL OR 1-YLMETHYL)-4-(POLYAZOL-1-YLMETHYL)-1,3-DIOXOLANES, European journal of medicinal chemistry, 32(7-8), 1997, pp. 637-650
Citations number
21
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
32
Issue
7-8
Year of publication
1997
Pages
637 - 650
Database
ISI
SICI code
0223-5234(1997)32:7-8<637:SAAASO>2.0.ZU;2-D
Abstract
A series of 2-(alkyl or aryl)-2-(alkyl or 1-ylmethyl)-4-(polyazol-1-yl methyl)-1,3-dioxolanes Ia-u was synthesized and tested in vitro agains t pathogenic fungi in man, animals and plants: Candida albicans, Asper gillus flavus and Fusarium solani. Compounds Iq-t with two polyazol gr oups have an in vitro activity against these fungi with MIC (minimum i nhibitory concentration) value of 5 mu g mL(-1).