Ifosfamide, epirubicin and granulocyte colony-stimulating factor: A regimen for successful mobilization of peripheral blood progenitor cells in patients with multiple myeloma

In general. the mobilization of peripheral blood progenitor cells (PBPC) in multiple myeloma (MM) patients is poor and is achieved in most cases by co mbined cyclophosphamide and G-CSF. This study was performed to examine the efficacy of combined ifosfamide/epirubicine and G-CSF for PBPC mobilization and purging. Sixteen patients suffering from multiple myeloma in stage II/ A and III/A according to Durie and Salmon underwent chemotherapy consisting of a total of three cycles of ifosfamide (3 g/m(2) on days 1 and 2 and epi rubicine 80 mg/m(2) on day 1) and C-CSF (10 or 20 mug/kg body weight (BW) d aily until harvesting). PBPC harvesting was performed after the first and t hird cycle of chemotherapy. The median number of PBPC after the first cycle of chemotherapy was 7.79 x 10(6) CD34 + cells/kg BW (ranging from 0.91-26. 36 x 10(6)) and 6.38 x 10(6) CD34 + cells/kg BW (ranging from 0.79-29.31 x 10(6)) after the third cycle of chemotherapy. Clinical re-evaluation after three cycles of chemotherapy showed 13 (81 per cent) patients in partial re mission (PR), two (12 per cent) in complete remission ICR) and one (6.25 pe r cent) in stable disease (SD). No major side-effects were observed. six pa tients developed hematological toxicity stage IV WHO for a median of 3.9 da ys but no serious infection episodes occurred. Combined ifosfamide/epirubic in and standard G-CSF is able to mobilize sufficient PBPC without serious s ide-effects for patients with MM and for purging procedures resulting in a high proportion of complete remissions after tandem high-dose melphalan che motherapy. Copyright (C), 2001 John Wiley & Sons. Ltd.