ANTIDIABETIC EFFECT OF SEISHIN-KANRO-TO IN KK-AY MICE

The hypoglycemic effect of Seishin-kanro-to (SK) was investigated in K K-Ay mice, one of the nora-insulin dependent diabetic mellitus types. SK (1700 mg/kg) reduced the blood glucose of KK-Ay mice from 557 +/- 1 7 to 383 +/- 36 mg/100 ml 7 hours after single oral administration (P < 0.001). SK also decreased the blood glucose and improved glucose tol erance 5 weeks after repeated administration in KK-ASI mise. These res ults support, therefore, the use of SK in patients with diabetes and c onfirm its role as a traditional medicine, in addition, the active pla nts of SK were identified as the rhizome of Anemarrhena osphodeloides Bunge and the radix of Rehmannia glutinosa Liboschitz.