Feedback control of a biodynamical model of HIV-1

Authors
Brandt, ME Chen, GR
Citation
Me. Brandt et Gr. Chen, Feedback control of a biodynamical model of HIV-1, IEEE BIOMED, 48(7), 2001, pp. 754-759
Citations number
19
Categorie Soggetti
Multidisciplinary,"Instrumentation & Measurement
Journal title
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
ISSN journal
00189294 → ACNP
Volume
48
Issue
7
Year of publication
2001
Pages
754 - 759
Database
ISI
SICI code
0018-9294(200107)48:7<754:FCOABM>2.0.ZU;2-F
Abstract
We describe a continuous differential equation model of the interaction dyn amics of HIV-1 and CD4 and CD8 lymphocytes in the human body. We demonstrat e several methods of stable control of the HIV-1 population using an extern al feedback control term that is analogous to the introduction of a therape utic drug regimen. We also show how the immune system components can be bol stered against the virus through a feedback control approach.