Synthesis and antimycotic activity of substituted 4-aminoacetyl-3-nitro-4 '-methyl diphenyl amines and 4-(2-aminothiazole-4-yl)-3-nitro-4 '-methyldiphenylamines

Synthesis of alpha -bromoacetyl-3-nitro-4 ' -methyl diphenylamine (6) was d one by bromination of 4-acetyl-3-nitro-4 ' -methyl diphenylamine (2) which was condensed with primary amines, secondary amines, thiourea and phenylthi ourea to form the corresponding substituted 4-aminoacetyl-3-nitro-4 ' -meth yl-diphenyl (7-9) and 4-(2-aminothiazole-4-yl)-3-nitro-4 ' -methyl diphenyl amines (10,11). The. structures of the synthesized compounds were supported by elemental analysis, and IR spectral data. The homogeneity and purity of the compounds were checked th rough TLC. The compounds were screened for i n vitro antifungal activity against Candida abicans, Cryptococcus neoforman s, Sporotrichum schenckii, Trichopyton mentagrophytes and Aspergillus fumig atus. Amongst these compounds 1,2,6,10 and 11 have been found to possess pr omising antifungal activity.