Correlation between cystatin C and serum creatinine as markers of renal function in patients with neoplasms of the locomotor system

Creatinine levels and clearance are used to monitor renal function in clini cal practice, Cystatin C is produced by most nucleated cells its a consiste nt manner, uninfluenced by inflammatory processes, sex, age, eating habits or nutritional status. Serum cystatin C concentrations are mainly dependent on glomerular activity and are an endogenous biochemical marker of glomeru lar filtration. The aim of this study was to test the efficiency of cystati n C assay as an alternative marker of renal function, Statistical analysis of our results showed that cystatin C levels were significantly correlated to creatinine and creatinine clearance levels. However, it is still prematu re to suppose that cystatin C can replace creatinine in routine tests, Esta blishing cystatin C levels can be useful in cases in which it is not possib le to determine creatinine clearance.