We report the first case in the English literature of an intramural duodena
l hematoma presenting as a complication of Helicobacter pylori-induced pept
ic ulcer disease. Intramural duodenal hematomas have been previously descri
bed in patients-usually in the setting of blunt trauma, postendoscopic biop
sy gastrostomy placement, and hemostatic therapy and in patients with a coa
gulopathy or bleeding diathesis-but not as a presentation of peptic ulcer d
isease. It is important to recognize this complication, as surgical managem
ent may benefit patients with a duodenal hematoma.