Liver penetration by a duodenal ulcer in a young woman

Liver penetration is a rare but serious complication of peptic ulcer diseas e. We report a case of a 33-year-old woman who took large doses of nonstero idal antiinflammatory drugs and developed a giant duodenal ulcer that penet rated into her liver. The diagnosis was based on histologic examination of endoscopic biopsies. She was initially treated with a proton pump inhibitor , but, within 5 weeks, she developed a symptomatic postbulbar stricture tha t required surgical correction. We also review II other reported cases of e ndoscopically and histologically diagnosed peptic ulcer penetration into th e liver.