Synthesis of a new fluoro-Wang resin for solid-phase reaction monitoring by F-19 NMR spectroscopy

A new fluoro-Wang resin is present-ed which facilitates solid-phase reactio n monitoring using F-19 NMR. The resin is easily synthesized and amenable t o scale-up. The method described herein compliments single-bead FT-IR-and C -13 NMR techniques. This method allows monitoring of solid-phase reactions even if the resin bound intermediate is unstable to the cleavage conditions . In addition, this is a useful tool to study reaction kinetics on the soli d phase.