M. Rangel et al., Cytotoxic and neurotoxic activities in extracts of marine sponges (Porifera) from southeastern Brazilian coast, J EXP MAR B, 262(1), 2001, pp. 31-40
Citations number
37
Categorie Soggetti
Aquatic Sciences
Journal title
JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY
This work reports the results of a screening program based on marine sponge
extracts from the southeastern Brazilian coast, covering cytotoxic and neu
rotoxic activities. Polar and non-polar extracts of 24 sponge species colle
cted by scuba diving in rocky shores, from 1996 to 2000, were screened for
haemolytic, cytotoxic and neurotoxic activities. Fifty-four percent (13/24)
of the sponge extracts tested exhibited from median to high toxicity in at
least one of the toxicity bioassays performed. Amphimedon sp, and Arenoscl
era brasiliensis Muricy and Ribeiro, 1999 induced haemolysis in mice erythr
ocytes at small concentrations. Aaptos sp. and Geodia corticostylifera Hajd
u, Muricy, Custodio, Russo and Peixinho, 1992 extracts lysed the sea-urchin
eggs, while Axinella aff. corrugata George and Wilson, 1919, Mycale laxiss
ima Duchassaing and Michelotti, 1864, A. Brasiliensis and Raspailia elegans
Bourm-Esnauls, 1973, inhibited mitosis and its development. The extracts o
f G. gibberosa Lamarck, 1815 and Stelletta sp. showed specific neurotoxic a
ctivity, while G, corticostylifera and A. brasiliensis extracts induced blo
ckage of action potential conduction in crustacean nerve, maybe due to thei
r lytic properties. (C) 2001 Elsevier Science B.V. All rights reserved.