THE SYNTHESIS AND PROPERTIES OF ENE)-1,7,10,16-TETRAOXA-4,13-DIAZA-CYCLOOCTADECANE

The title compound ene)-1,7,10,16-tetraoxa-4,13-diazacyclooctadecane, 5 was obtained by a Mannich condensation starting from 3-hydroxy-6-met hyl-4H-pyran-4-one, 3, Kryptofix 22, 4 and formaldehyde. The structure of this product was proved by spectral investigations (UV-VIS, IR, H- 1-, and C-13-NMR). In agreement with the admitted structure, compound 5 shows hydrophobicity and chelating properties. The protonation const ants of both 3'-hydroxyl groups and of the two nitrogen atoms were det ermined together with the isoelectric pH value.