Synthesis of the [H-3] labelled potent and selective peripheral benzodiazepine receptor ligand CB 34

Authors
Latrofa, A Trapani, G Franco, M Harris, MJ Serra, M Biggio, G Liso, G
Citation
A. Latrofa et al., Synthesis of the [H-3] labelled potent and selective peripheral benzodiazepine receptor ligand CB 34, J LABEL C R, 44(7), 2001, pp. 521-528
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
44
Issue
7
Year of publication
2001
Pages
521 - 528
Database
ISI
SICI code
0362-4803(200106)44:7<521:SOT[LP>2.0.ZU;2-Y
Abstract
The synthesis of the [H-3] labelled peripheral benzodiazepine receptor (PBR ) ligand CB 34, useful for binding assay, tissue distribution studies, and elucidation of the physiological role of PER, is described. Catalytic reduc tion with H-3(2) gas and 10% Pd/C catalyst of the key intermediate 2 afford ed the product at a specific activity of 111 Ci/mmol. Copyright (C) 2001 Jo hn Wiley & Sons, Ltd.