Synthesis and deuterium labeling of some 4-phenyl, 3-substituted isochromanes

Authors
Guyard, AL Valleix, A Rousseau, B Cintrat, JC
Citation
Al. Guyard et al., Synthesis and deuterium labeling of some 4-phenyl, 3-substituted isochromanes, J LABEL C R, 44(7), 2001, pp. 529-539
Citations number
21
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
44
Issue
7
Year of publication
2001
Pages
529 - 539
Database
ISI
SICI code
0362-4803(200106)44:7<529:SADLOS>2.0.ZU;2-9
Abstract
The preparation of a number of 4-phenyl isochromanes as well as the deutera ted analogs is described using a simple strategy starting from easily obtai ned acetals. The diasteresoselectivity and the enantioselectivity of the ad opted approach are both good. The deuterated analogs are prepared using tri butyltin deuteride or triethyl deuterosilane. Copyright (C) 2001 John Wiley & Sons, Ltd.