Cohen syndrome with acanthosis nigricans and insulin resistance

Cohen syndrome is a rare genetic disorder consisting of truncal obesity, hy potonia, mental retardation, microcephalia, characteristic facial appearanc e and ocular anomalies. Other diagnostic clinical features include narrow h ands and feet, low growth parameters, neutropenia and chorioretinal dystrop hy, Acanthosis nigricans is a cutaneous disorder characterized by hyperpigm entation and papillomatosis. Syndromal acanthosis nigricans may occasionall y appear as a feature of several specific syndromes. We report a patient sh owing the typical characteristics of Cohen syndrome with acanthosis nigrica ns and hyperinsulinemia.