I. Schimke et al., Decreased oxidative stress in patients with idiopathic dilated cardiomyopathy one year after immunoglobulin adsorption, J AM COL C, 38(1), 2001, pp. 178-183
Citations number
25
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Objectives In a substudy to a recently reported investigation that demonstr
ated the benefit of immunoglobulin adsorption (immunoadsorption) for patien
ts with idiopathic dilated cardiomyopathy (IDC), we tested whether this ben
efit is associated with a reduction of oxidative stress.
Background The progression of cardiomyopathy is believed to be related to t
he increase of oxidative stress. Therefore, reduction of oxidative stress c
ould be one of the effects of immunoadsorption for improvement of cardiac p
erformance and clinical status.
Methods Plasma markers for oxidative stress-thiobarbituric acid-reactive su
bstances (TBARS), lipid peroxides (LPO), anti-oxidized low-density lipoprot
ein-autoantibodies (anti-oxLDL-AB), thiol groups and vitamin E-were compare
d in 31 patients, of whom 16 underwent immunoadsorption and 15 received con
ventional treatment (controls). All patients received a daily supplement of
vitamins, minerals and trace elements.
Results After one year, TEARS (p = 0.026), LPO (p = 0.026) and anti-oxLDL-A
B (p = 0.044) were decreased in the immunoadsorption group bile not in the
controls. Thiols were unchanged in the immunoadsorption group but were decr
eased in the controls (p = 0.001). Vitamin E accumulated in both groups (im
munoadsorption: p = 0.001; controls: p = 0.031) with a trend for stronger a
ccumulation after immunoadsorption (p = 0.09). Prior to the study, the anti
-oxLDL-AB to left ventricular ejection fraction (LVEF) (p = 0.05) were inve
rsely correlated. After one year, correlations with borderline significance
were calculated for TEARS to New York Heart Association functional class (
p = 0.081) and inversely for LPO to LVEF (p = 0.083).
Conclusions Effective therapy in patients with IDC, such as immunoadsorptio
n which improved cardiac performance and clinical status, is associated wit
h a reduction of oxidative stress. (J Am Coll Cardiol 2001;38:178-83) (C) 2
001 by the American College of Cardiology.