Improved catalytic procedures for the copper(I)-promoted reactions of beta-amido zinc reagents

Authors
Hunter, C Jackson, RFW Rami, HK
Citation
C. Hunter et al., Improved catalytic procedures for the copper(I)-promoted reactions of beta-amido zinc reagents, J CHEM S P1, (12), 2001, pp. 1349-1352
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14727781 → ACNP
Issue
12
Year of publication
2001
Pages
1349 - 1352
Database
ISI
SICI code
1472-7781(2001):12<1349:ICPFTC>2.0.ZU;2-F
Abstract
Copper-catalysed cross coupling of the beta -aminoalkylzinc reagents 1a and 2 with unsaturated alkyl halides gives beta -unsaturated ethylamines in 47 -78% yield (4 examples) and enantiomerically pure beta -unsaturated propyla mines in 55-69% yield (3 examples). This method is more efficient for simpl e beta -aminoalkylzinc reagents than that using stoichiometric copper.