Palladium catalysed coupling reactions of 6-O-tert-butyldimethylsilyl-1-bro
mocodeine and 6-O-tert-butyldimethylsilyl-3-triuoromethylsulfonylmorphine a
llow a range of substituted analogues of codeine in the 1-position and morp
hine in the 3-position to be efficiently and selectively prepared.