Comparison between Eppendorf-histograph and the Licox-system in tumor tissue oxygen measurement

The oxygenation of a tumor is certainly one of the major facts influencing the response to treatment. pO(2) measurement in tumor tissue can be done by using the Eppendorf-histograph. In recent years the ticox-system (GMS) was developed for oxygen tension measurement in tissues and fluids under clini cal routine conditions and for research work. Aim of the present: study was to assess the suitability of the Licox-system in drawing up histograms of pO(2) values in tumor tissues. Method: Histograms of the distribution of ox ygen tension in twelve tumors were prepared with both measuring systems in parallel. Investigations were performed on rats with isotransplanted R1H rh abdomyosarcomas in continuous intravenous anesthesia with Fentanyl and Dorm icum, Ventilation with a mixture of air and oxygen was applied through a tr acheostoma. Arterial pressure and body temperature were analysed and balanc ed continously. Results: No correspondence between data of both measuring m ethods could be found. Conclusions: Because of constructional advantages th e Eppendorf-histograph seems to be comparatively more suitable in drawing u p histograms of oxygen tension tumor tissue.