Novel thermoreversible gelation of biodegradable PLGA-block-PEO-block-PLGAtriblock copolymers in aqueous solution

Authors
Lee, DS Shim, MS Kim, SW Lee, H Park, I Chang, TY
Citation
Ds. Lee et al., Novel thermoreversible gelation of biodegradable PLGA-block-PEO-block-PLGAtriblock copolymers in aqueous solution, MACRO RAPID, 22(8), 2001, pp. 587-592
Citations number
26
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
MACROMOLECULAR RAPID COMMUNICATIONS
ISSN journal
10221336 → ACNP
Volume
22
Issue
8
Year of publication
2001
Pages
587 - 592
Database
ISI
SICI code
1022-1336(20010615)22:8<587:NTGOBP>2.0.ZU;2-U
Abstract
The BAB-type triblock copolymers composed of a central poly(ethylene oxide) (PEO, (M) over bar (nPEO) = 1000) block and two poly[(D,L-lactic acid)-co( glycolic acid)] end blocks with molecular weights between 900 and 1600 exhi bited an interesting phase transition behaviour. The copolymer aqueous solu tion can form micelles with PLGA loops in the core and a PEO shell and grou ps of micelles because of bridging between micelles caused by the PLGA bloc ks with raising temperature. A possible micellar gelation mechanism was sug gested.