MOTOR-NEURON DISEASE FOLLOWING GENERALIZED FASCICULATIONS AND CRAMPS

We report a case of motor neuron disease in which fasciculations and c ramps progressed generally before the development of muscle wasting. A fter involvement of the upper and lower motor neurons became clinicall y manifest, widespread fasciculations and cramps persisted and accompa nied pseudotetany. The present case suggests that spinal cord patholog y of motor neuron disease can cause the abnormal excitability of the m otor neurons, resulting in the development of generalized fasciculatio ns and cramps. (C) 1997 Elsevier Science B.V.