Zyvox (linezolid) - a new-generation antibiotic effective in bacterial infections

Citation
Z. Glinski et K. Kostro, Zyvox (linezolid) - a new-generation antibiotic effective in bacterial infections, MED WETER, 57(7), 2001, pp. 469-471
Citations number
14
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
MEDYCYNA WETERYNARYJNA
ISSN journal
00258628 → ACNP
Volume
57
Issue
7
Year of publication
2001
Pages
469 - 471
Database
ISI
SICI code
0025-8628(200107)57:7<469:Z(-ANA>2.0.ZU;2-Q
Abstract
The rapid emergence of multi-drug resistant bacterial strains and the poten tial threat they pose to humans and animals initiated research into finding a new type of antibiotic. Zyvox (linezolid), a new synthetic antibiotic of the oxazolidinone group is very effective in treating infections caused by Gram positive bacteria resistant to known antibiotics and other chemical t reatments. It is the first antibiotic approved to treat patients with serio us or life-threatening infections caused by methicillin-resistant Staphyloc occus aureus, penicillin- resistant pneumococci and vancomycin-resistant en terococci. Zyvox is rapidly absorbed from the alimentary canal, reaches pea k plasma concentration after 1.5 h, has a terminal half-life of 5-7 h and o nly 30% of the antibiotic binds to plasma proteins.