Ev. Korotkov et Ma. Korotkova, Occurrence of MIR elements in the complete nucleotide sequence of human chromosome 22, MOL BIOL, 35(3), 2001, pp. 318-323
The location of mammalian interspersed repeats (MIRs) and their density hav
e been determined in the complete nucleotide sequence of human chromosome 2
2. The approach developed by us has allowed detection of 9675 MIRs at a sta
tistically significant level, which by 15% exceeds the MIR number revealed
by all previous approaches. It has been demonstrated that a considerable am
ount of MIRs missed by the algorithms applied earlier occurs in known DNA s
equences of the human genome. The study of the MIR density revealed substan
tial irregularity of their distribution along the chromosome. The data on t
he MIRs thus found and the computer program searching for diverged sequence
s are available by E-mail: katrin2@mail.ru or katrin22@mtu-net.ru.