Occurrence of MIR elements in the complete nucleotide sequence of human chromosome 22

Citation
Ev. Korotkov et Ma. Korotkova, Occurrence of MIR elements in the complete nucleotide sequence of human chromosome 22, MOL BIOL, 35(3), 2001, pp. 318-323
Citations number
20
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY
ISSN journal
00268933 → ACNP
Volume
35
Issue
3
Year of publication
2001
Pages
318 - 323
Database
ISI
SICI code
0026-8933(200105/06)35:3<318:OOMEIT>2.0.ZU;2-G
Abstract
The location of mammalian interspersed repeats (MIRs) and their density hav e been determined in the complete nucleotide sequence of human chromosome 2 2. The approach developed by us has allowed detection of 9675 MIRs at a sta tistically significant level, which by 15% exceeds the MIR number revealed by all previous approaches. It has been demonstrated that a considerable am ount of MIRs missed by the algorithms applied earlier occurs in known DNA s equences of the human genome. The study of the MIR density revealed substan tial irregularity of their distribution along the chromosome. The data on t he MIRs thus found and the computer program searching for diverged sequence s are available by E-mail: katrin2@mail.ru or katrin22@mtu-net.ru.