Insertion/deletion polymorphism of the serotonin transporter gene and neuroticism as a temperament trait in affective patients and healthy individuals

Some studies associate the insertion/deletion polymorphism of the serotonin transporter (5-HTT) gene with anxiety related personality traits in mental ly healthy people, the short (s) allele being associated with a higher neur oticism score. The 5-HTT genotype and neuroticism score were established fu r 114 affective patients, 87 healthy relatives of endogenous psychosis pati ents, and for 156 mentally healthy people without familial psychiatric hist ory. The effects of sex and age on the association between the two paramete rs was studied. Neuroticism proved to be not associated with the 5-HTT geno type.