Ky. Kropachev et al., The effect of hepatocarcinogen o-aminoazotoluene on induction of mouse liver tyrosine aminotransferase by glucocorticoids, MOL BIOL, 35(3), 2001, pp. 392-398
o-Aminoazotoluene (OAT) suppressed more than twofold the glucocorticoid ind
uction of tyrosine aminotransferase in the liver of SWR mice, which are sen
sitive to the hepatocarcinogenic effect of OAT, hut not in resistant AKR mi
ce. The hormone- and DNA-binding activities of the glucocorticoid receptor
were not affected in either strain. The OAT-dependent suppression proved to
he associated with a decrease in the DNA-binding activity of HNF3 in liver
cell extracts. The content of the HNF3 mRNA did not change, suggesting a p
osttranscriptional effect of OAT.