The effect of hepatocarcinogen o-aminoazotoluene on induction of mouse liver tyrosine aminotransferase by glucocorticoids

Authors
Kropachev, KY Kaledin, VI Timofeeva, OA Il'nitskaya, SI Vasil'eva, ED Plisov, SY Rychkova, NA Filipenko, ML Merkulova, TI
Citation
Ky. Kropachev et al., The effect of hepatocarcinogen o-aminoazotoluene on induction of mouse liver tyrosine aminotransferase by glucocorticoids, MOL BIOL, 35(3), 2001, pp. 392-398
Citations number
46
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR BIOLOGY
ISSN journal
00268933 → ACNP
Volume
35
Issue
3
Year of publication
2001
Pages
392 - 398
Database
ISI
SICI code
0026-8933(200105/06)35:3<392:TEOHOO>2.0.ZU;2-L
Abstract
o-Aminoazotoluene (OAT) suppressed more than twofold the glucocorticoid ind uction of tyrosine aminotransferase in the liver of SWR mice, which are sen sitive to the hepatocarcinogenic effect of OAT, hut not in resistant AKR mi ce. The hormone- and DNA-binding activities of the glucocorticoid receptor were not affected in either strain. The OAT-dependent suppression proved to he associated with a decrease in the DNA-binding activity of HNF3 in liver cell extracts. The content of the HNF3 mRNA did not change, suggesting a p osttranscriptional effect of OAT.