Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological ageing of nondividing cells

Citation
N. Harris et al., Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological ageing of nondividing cells, MOL GENET G, 265(2), 2001, pp. 258-263
Citations number
42
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR GENETICS AND GENOMICS
ISSN journal
16174615 → ACNP
Volume
265
Issue
2
Year of publication
2001
Pages
258 - 263
Database
ISI
SICI code
1617-4615(200104)265:2<258:ISCSRT>2.0.ZU;2-5
Abstract
Recent studies on Drosophila and Caenorhabditis elegans indicate that incre ases in stress resistance result in a longer chronological life span, an ef fect that must operate primarily on the postmitotic tissues of the adult. S tress resistance can be increased through decreases In Hsp90 chaperone acti vity, since Hsp90 acts to downregulate the activity of heat shock transcrip tion factor. This study investigated whether the increases in stress resist ance associated with reduced Hsp90 chaperone activity influence ageing in t he budding yeast Saccharomyces cerevisiae, ageing being measured either as the replicative (nonchronological) senescence of budding cells or as the ch ronological ageing of non-dividing (stationary phase) cultures. Overactivat ion of the heat shock response caused no slowing of replicative senescence. In some situations though it was associated with a longer chronological li fe span of stationary cells, the yeast equivalent of the postmitotic state. This is consistent With the idea that stress resistance exerts its life sp an-extending effects primarily in postmitotic cells and tissues.