Quantitative trait loci (QTLs) associated with resistance/susceptibility to infectious pancreatic necrosis virus (IPNV) in rainbow trout (Oncorhynchus mykiss)

Authors
Ozaki, A Sakamoto, T Khoo, S Nakamura, K Coimbra, MRM Akutsu, T Okamoto, N
Citation
A. Ozaki et al., Quantitative trait loci (QTLs) associated with resistance/susceptibility to infectious pancreatic necrosis virus (IPNV) in rainbow trout (Oncorhynchus mykiss), MOL GENET G, 265(1), 2001, pp. 23-31
Citations number
30
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR GENETICS AND GENOMICS
ISSN journal
16174615 → ACNP
Volume
265
Issue
1
Year of publication
2001
Pages
23 - 31
Database
ISI
SICI code
1617-4615(200103)265:1<23:QTL(AW>2.0.ZU;2-0
Abstract
Infectious pancreatic necrosis (IPN) is a well-known acute viral disease of salmonid species. We have identified quantitative trait loci (QTLs) associ ated with resistance to this disease in rainbow trout. We searched for link age among 51 microsatellite markers used to construct a framework linkage m ap in backcross families of rainbow trout (Oncorhynchus mykiss), produced b y crossing IPN-resistant (YN-RT201) and -susceptible (YK-RT101) strains. Tw o putative QTLs affecting disease resistance were detected on chromosomes A (IPN R/S-1) and C (IPN R/S-2), respectively, suggesting that this is a pol ygenic trait in rainbow trout. These markers have great potential for use i n marker-assisted selection (MAS) for IPN resistance and provide the basis for cloning of IPN resistance genes. Clarification of the genetic bases of complex traits has broad implications for fundamental research, but will al so be of practical benefit to fish breeding.